God-awful good-for-nothing figures from cutting-edge published research.
August 23, 2012
FIGURE 3. Mapping metabolome regulation on biochemical networks.
Fiehn O, Barupal DK, Kind T (2011) Extending biochemical databases by metabolomic surveys. J Biol Chem 286: 23637-23643
Shown is the regulation of the human ileal effluent metabolome after versus
before ileostomy surgery (70), magnified for the carbohydrate cluster. Iden-
tified metabolites are mapped to the biochemical KEGG RPAIR Database and
chemical similarity (green edges, dashed if Ͻ600 similarity), spanning a net-
work displayed in Cytoscape. Unknown metabolites (BinBase Metabolome
Database numbers (48)) are added by mass spectral similarity (red edges,
dashed if Ͻ600 similarity). Red node metabolites are significantly increased in
concentration (p Ͻ 0.05), blue nodes mark decreased compounds, and yellow
nodes (small print) are not regulated. Node size indicates magnitude of
August 6, 2012
Qi X, Chen Y, Jiang K, Zuo W, Luo Z, Wei Y, Dub L, Wei H, Huanga R, Du Q (2012) Saturation-Mutagenesis in Two Positions Distant from Active Site of a Klebsiella pneumoniae Glycerol Dehydratase Identifies Some Highly Active Mutants. Journal of Biotechnology, 144(1):43-50. doi:10.1016/j.jbiotec.2009.06.015
Superimposition of 20 models of the β-subunit with position β-42 mutation, built by computer programs. Arrow indicates the area of this mutated position.
June 9, 2012
Figure 5. Regression tree for foraging activity.
Each split corresponds to a rule which is displayed with the variable causing the split (Condition
Threlfall CG, Law B, Banks PB (2012) Influence of Landscape Structure and Human Modifications on Insect Biomass and Bat Foraging Activity in an Urban Landscape. PLoS ONE 7(6): e38800. doi:10.1371/journal.pone.0038800
February 16, 2012
On the cover: Caveolin-1 is a major structural component of lipid rafts. On pp. 171–185 of this issue, Wernstedt Asterholm and colleagues show that lack of caveolin-1 in mice results in decreased circulating levels of adiponectin and a reduced ability to alter substrate use in response to feeding/fasting conditions. Adipose tissue mitochondrial dysfunction, an elevated rate of lipolysis, and a constitutive increase in hepatic glucose output lead to a reduced ability to adjust to altered fuel supply and a systemic overreliance on carbohydrates. The cover art depicts the complex systemic changes observed in caveolin-1 null mice.
Asterholm IW, Mundy DI, Weng J, Anderson RGW, Scherer PE. (2012). Altered Mitochondrial Function and Metabolic Inﬂexibility Associated with Loss of Caveolin-1. Cell Metabolism Volume 15, Issue 2 Cover & 171–185 doi:10.1016/j.cmet.2012.01.004
January 24, 2012
Comparison of ratios of DNABIT Compress with existing algorithms
Rajarajeswari, P., & Apparao, A. (2011). DNABIT Compress – Genome compression algorithm. Bioinformation, 5(8), 350-360.
January 19, 2012
Gutiérrez AIM, Zarazaga MRE, Damme SV. (2011). The Role of Anxiety Sensitivity, Fear of Pain and Experiential Avoidance in Experimental Pain. Psychology. Vol.2, No.8, 817-823 doi:10.4236/psych.2011.28125
Relationships between psicosocial antecedent variables, factors and dependent variables.
November 29, 2011
Schout, G., de Jong, G., Zeelen, J. (2011). Beyond Care Avoidance and Care Paralysis: Theorizing Public Mental Health Care. Sociology. 45:665 DOI:10.1177/0038038511406591
November 28, 2011
Severino, S., Messina, R. (2011). Group Dynamics in On-Line and Face-to-Face Interactions: An Experimental Study on Learning Methods. Sociology Mind. Vol.1, No.2, 65-73 DOI:10.4236/sm.2011.12008
November 15, 2011
Anderson RG, 1982 Mutations that affect membrane receptor for LDL are useful for studying normal receptor function. Am J Physiol. 1982 Jul;243(1):E5-14.
November 8, 2011
Only good diseases will find it through.
Figure 3. Human DRNs from pathway-level analysis for 61 diseases and phenotypes. Analysis for five populations: CEU (A), CHB (B), JPT (C), CHB+JPT (D), and YRI (E). The edge width and color correspond to the Jaccard indexes for each disease pair. Line width and color is scaled the same as in Figure 2. The inserted table lists index cutoff values for each line color designation.
Lewis SN, Nsoesie E, Weeks C, Qiao D, Zhang L, 2011 Prediction of Disease and Phenotype Associations from Genome-Wide Association Studies. PLoS ONE 6(11): e27175. doi:10.1371/journal.pone.0027175.g003